Related Experiment Video
Updated: Jul 19, 2025
09:29
Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
Published on: October 29, 2015
30.3K
Direct-acting Antivirals for Hepatitis C and Implication for Community Pharmacy Practice.
Sara McEntee1, Yifei Liu2, Tahar Mahmoudi3
1Walgreens Health-System Pharmacy #10845, Kansas City, MO, USA.
Current Pharmaceutical Design
|August 16, 2023
Summary
Direct-acting antivirals (DAAs) have transformed hepatitis C treatment. Pharmacists play a key role in guiding individualized DAA selection and improving patient adherence in community pharmacy settings.
Area of Science:
- Hepatology
- Pharmacology
- Infectious Diseases
Background:
- Hepatitis C treatment has advanced significantly with the advent of direct-acting antivirals (DAAs).
- Selecting the optimal DAA regimen requires consideration of patient-specific factors like genotype, prior treatment, comorbidities, and other medications.
- Pharmacists are integral to patient care, offering crucial guidance on DAA selection and management.
Purpose of the Study:
- To provide a comprehensive overview of currently available direct-acting antiviral therapies for hepatitis C.
- To delineate the implications of DAA therapy for patient care within community pharmacy settings.
Main Methods:
- This commentary synthesizes current literature on direct-acting antivirals for hepatitis C.
- It outlines the role of community pharmacists in optimizing DAA therapy selection and management.
- Key considerations for individualized treatment and patient support are discussed.
Main Results:
- Direct-acting antivirals offer effective treatment options for hepatitis C, with selection tailored to individual patient profiles.
- Community pharmacists can effectively contribute to hepatitis C management by recommending appropriate DAAs and monitoring treatment.
- Pharmacist-led interventions can enhance medication adherence and ensure timely laboratory monitoring.
Conclusions:
- Community pharmacists are well-positioned to guide the selection of individualized direct-acting antiviral therapies for hepatitis C.
- Implementing specific workflows can empower pharmacists to identify drug interactions and improve patient compliance.
- Pharmacists are essential in maximizing the effectiveness of direct-acting antiviral treatment and improving patient outcomes.
Related Concept Videos
01:10Retrovirus Life Cycles
46.2K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
46.2K
01:18Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
1.2K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
1.2K
01:16Hepatic Drug Excretion: Influencing Factors
154
The biliary system of the liver, crucial for bile secretion and drug excretion, comprises intrahepatic bile ducts that merge to form the common hepatic duct. This duct, carrying hepatic bile, combines with the cystic duct, draining the gallbladder and forming the common bile duct, which empties into the duodenum. Bile, produced by hepatic cells lining the bile canaliculi, is composed primarily of water, bile salts, pigments, electrolytes, and lesser amounts of cholesterol and fatty acids. Bile...
154
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
753
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
753
01:14Hepatic Drug Clearance: Role of Transporters
86
In the liver and bile canaliculi, influx and efflux transporters modification can influence intrinsic clearance. Transporters play a significant role in moving drugs within liver cells. Elaborate models, such as the Biopharmaceutical Classification System (BCS), are essential to relate transporters to drug disposition. This system categorizes drugs into four classes based on solubility and permeability, providing insights into elimination routes and the effects of transporters following oral...
86
01:20Lipid-Lowering Drugs: Statins and Miscellaneous Agents
699
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
699