Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...

Integration of Synaptic Events

Integration of Synaptic Events

Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cell wall dynamics and biomechanics of root hair morphogenesis.

Journal of experimental botany·2026

Same author

The carbohydrate-binding module of TrCel7A aids in navigating hemicellulose barriers in plant cell walls.

The Journal of biological chemistry·2026

Same author

Mechanical constraint causes lower turgor, thicker walls, and faster growth in Arabidopsis root hairs.

Plant physiology·2026

Same author

Biomarkers in Spinal Metastasis of Breast Cancer: Insights Into Survival and Functional Outcomes.

Journal of clinical neurology (Seoul, Korea)·2026

Same author

Context-dependent effects of SOM neurons to enhance the responses of corticocollicular neurons to repetitive sounds.

iScience·2026

Same author

Utility of direct wave intraoperative neuromonitoring for intramedullary spinal cord tumor resection.

Journal of neurosurgery. Spine·2026

Search research articles

Related Experiment Video

Updated: Jul 19, 2025

Long-term Potentiation of Perforant Pathway-dentate Gyrus Synapse in Freely Behaving Mice

Long-term Potentiation of Perforant Pathway-dentate Gyrus Synapse in Freely Behaving Mice

Published on: November 29, 2013

Synaptic zinc potentiates AMPA receptor function in mouse auditory cortex.

Philip T R Bender¹, Mason McCollum¹, Helen Boyd-Pratt¹

¹Department of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University School of Medicine, Morgantown, WV 26506, USA.

|August 16, 2023

Summary

This summary is machine-generated.

Synaptic zinc potentiates AMPA receptor function and influences auditory neuron tuning. This study reveals synapse- and cell-type-specific roles for zinc signaling in the cortex.

Keywords:

AMPA receptors CP: Neuroscience NMDA receptors Slc30a3 ZnT3 auditory cortex corticocallosal neurons corticocollicular neurons glutamate synaptic transmission synaptic zinc

More Related Videos

High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning

High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning

Published on: December 15, 2016

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation

Published on: June 26, 2013

Related Experiment Videos

Last Updated: Jul 19, 2025

Long-term Potentiation of Perforant Pathway-dentate Gyrus Synapse in Freely Behaving Mice

Long-term Potentiation of Perforant Pathway-dentate Gyrus Synapse in Freely Behaving Mice

Published on: November 29, 2013

High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning

High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning

Published on: December 15, 2016

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation

Published on: June 26, 2013

Area of Science:

Neuroscience
Cell Biology
Neurochemistry

Background:

Synaptic zinc signaling modulates neuronal activity.
Zinc is present in specific cortical neuron populations, suggesting a role in microcircuit diversity.
Understanding zinc's function in the cortex is crucial for comprehending neural processing.

Purpose of the Study:

To investigate the role of synaptic zinc in modulating synaptic activity and neuronal function in the mouse auditory cortex.
To determine how synaptic zinc affects AMPA receptor function and sound-frequency tuning in different neuron types.

Main Methods:

Whole-cell patch-clamp recordings from layer 5 intratelencephalic (IT) and pyramidal tract (PT) neurons.
Optogenetic stimulation of presynaptic neurons.
In vivo 2-photon calcium imaging in awake mice.

Main Results:

Synaptic zinc potentiates AMPA receptor (AMPAR) function in a synapse-specific manner.
Changes in synaptic zinc widen or sharpen sound-frequency tuning bandwidth in IT-type neurons.
Synaptic zinc primarily widens the sound-frequency tuning bandwidth of PT-type neurons.

Conclusions:

Synaptic zinc plays a critical role in modulating synaptic transmission and neuronal tuning in the auditory cortex.
The effects of synaptic zinc are specific to the synapse and the type of neuron.
These findings highlight the importance of zinc in the functional specificity of intracortical microcircuits.