Related Experiment Video
Updated: Jul 19, 2025

Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile
Published on: October 30, 2018
Visible-Light-Mediated Synthesis of α-Aryl Ester Derivatives via an EDA Complex
Yutong Liu1, Shuangqiao Li1, Xueqin Chen1
1School of Life Science and Engineering, Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, Southwest Jiaotong University, Chengdu 610031, China.
Abstract:
We report an efficient radical-based and photocatalyst-free method for the C(sp2)-C(sp3) cross-coupling reaction to synthesize α-aryl ester derivatives. The process starts from a β-keto ester and an electron-deficient halogenated aryl halide under alkaline conditions to form an electron donor-acceptor complex and is driven by visible light. From the synthetic point of view, this newly established method represents a simple way to access arylpropionic acids from commercially available and cheap starting materials.
More Related Videos
Related Concept Videos
Alkylation of β-Diester Enolates: Malonic Ester Synthesis
Synthesis of α-Substituted Carbonyl Compounds: The Stork Enamine Reaction
α-Hydroxy Ketones via Reductive Coupling of Esters: Acyloin Condensation Overview
Alkylation of β-Ketoester Enolates: Acetoacetic Ester Synthesis
Aldol Condensation with β-Diesters: Knoevenagel Condensation
Aryldiazonium Salts to Azo Dyes: Diazo Coupling

