Defluorinative Thiolation of gem-Difluoroalkenes by Convergent Paired Electrolysis
Zichen Pan1, Xiuqi Wang1, Shuaishuai Zhao2
1Institute of Material Physics and Chemistry, College of Science, Nanjing Forestry University, Nanjing, Jiangsu 210037, P. R. China.
Abstract:
Herein, we have successfully developed a convergent paired electrolysis strategy for the defluorinative thiolation process utilizing thiols and gem-difluoroalkenes as precursors. This protocol exhibits remarkable tolerance toward a wide range of functional groups, as exemplified by the successful late-stage defluorothiolation of complex molecules. Additionally, this strategy is amenable to gram-scale synthesis, making use of both anodic oxidation and cathodic reduction processes in an efficient manner. Several control studies were conducted and suggested a convergent paired electrolysis mechanism.
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