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Momordica charantia Enhances Tendon Healing in Rats: An Experimental Study
Furkan Erdoğan1, Arife Ahsen Kaplan2, Hüseyin Sina Coşkun3
1Clinic of Orthopaedic and Traumatology, Sabuncuoğlu Şerafeddin Training and Research Hospital, Amasya, Turkey.
Cells, Tissues, Organs
|August 16, 2023
Summary
Momordica charantia extract significantly enhances tendon healing by improving collagen production and tenoblastic activity. This traditional plant shows promise for effective tendon repair and regeneration.
Area of Science:
- Biomedical Science
- Regenerative Medicine
- Pharmacology
Background:
- Momordica charantia (MC) is a traditional herb with a history of use in wound healing.
- Tendon injuries require effective therapeutic strategies to promote repair and regeneration.
Purpose of the Study:
- To evaluate the efficacy of Momordica charantia (MC) extract in promoting tendon healing.
- To investigate the effects of MC on histological and biomechanical aspects of tendon repair.
Main Methods:
- Adult male Wistar albino rats underwent Achilles tendon surgery with different treatments: primary repair, collagen tube insertion, or MC extract application.
- Tendons were analyzed stereologically, histologically, and bioinformatically on postoperative day 40.
Main Results:
- MC extract and collagen tube groups showed increased collagen fiber volume compared to primary repair.
- MC administration improved tenoblastic activity, collagen production, and neovascularization.
- Bioinformatic analysis suggested MC proteases facilitate vasculogenesis, reduce inflammation, and aid collagen remodeling.
Conclusions:
- Momordica charantia extract effectively ameliorates injured tendon healing.
- MC extract demonstrates potential for satisfactory tendon repair and warrants further investigation.
