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Updated: Jul 19, 2025
08:14
A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9
Published on: August 28, 2018
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PCSK9 and the nervous system: a no-brainer?
Ali K Jaafar1, Romuald Techer1, Kévin Chemello1
1Laboratoire Inserm UMR 1188 DéTROI, Saint-Pierre, La Réunion, France.
Journal of Lipid Research
|August 16, 2023
Summary
Proprotein convertase subtilisin/kexin type 9 (PCSK9) impacts LDL cholesterol and cardiovascular health. This review explores PCSK9
Area of Science:
- Neuroscience
- Cardiovascular Science
- Molecular Biology
Background:
- Proprotein convertase subtilisin/kexin type 9 (PCSK9) is crucial for LDL receptor degradation and cholesterol metabolism.
- PCSK9 was initially identified in the brain, but its nervous system functions are not well understood.
Purpose of the Study:
- To comprehensively review PCSK9's expression, lipid metabolism effects, and roles in the central and peripheral nervous systems.
- To focus on PCSK9's involvement in cerebrovascular and neurodegenerative diseases.
Main Methods:
- Systematic literature review of studies published up to July 2023.
- Analysis of research on PCSK9 expression patterns and functional roles.
- Synthesis of findings related to neurological and cardiovascular implications.
Main Results:
- PCSK9 influences LDL receptor levels and lipid profiles.
- Evidence suggests PCSK9 has roles in both central and peripheral nervous systems.
- Emerging data links PCSK9 to neurodegenerative and cerebrovascular conditions.
Conclusions:
- PCSK9 is a significant factor in both lipid metabolism and neurological health.
- Further research is warranted to fully elucidate PCSK9's functions in the nervous system and its therapeutic potential for related diseases.
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