Related Experiment Video

Updated: Jul 19, 2025

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9
08:14

A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9

Published on: August 28, 2018

8.2K

PCSK9 and the nervous system: a no-brainer?

Ali K Jaafar1, Romuald Techer1, Kévin Chemello1

  • 1Laboratoire Inserm UMR 1188 DéTROI, Saint-Pierre, La Réunion, France.

Journal of Lipid Research
|August 16, 2023
PubMed

Insights

Proprotein convertase subtilisin/kexin type 9 (PCSK9) impacts LDL cholesterol and cardiovascular health. This review explores PCSK9

Area of Science:

  • Neuroscience
  • Cardiovascular Science
  • Molecular Biology

Background:

  • Proprotein convertase subtilisin/kexin type 9 (PCSK9) is crucial for LDL receptor degradation and cholesterol metabolism.
  • PCSK9 was initially identified in the brain, but its nervous system functions are not well understood.

Purpose of the Study:

  • To comprehensively review PCSK9's expression, lipid metabolism effects, and roles in the central and peripheral nervous systems.
  • To focus on PCSK9's involvement in cerebrovascular and neurodegenerative diseases.

Main Methods:

  • Systematic literature review of studies published up to July 2023.
  • Analysis of research on PCSK9 expression patterns and functional roles.
  • Synthesis of findings related to neurological and cardiovascular implications.

Main Results:

  • PCSK9 influences LDL receptor levels and lipid profiles.
  • Evidence suggests PCSK9 has roles in both central and peripheral nervous systems.
  • Emerging data links PCSK9 to neurodegenerative and cerebrovascular conditions.

Conclusions:

  • PCSK9 is a significant factor in both lipid metabolism and neurological health.
  • Further research is warranted to fully elucidate PCSK9's functions in the nervous system and its therapeutic potential for related diseases.
Keywords:
Alzheimer’s diseaseBrainLDL receptorNervous systemPCSK9Stroke

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