Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

407
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
407
Human Genetics01:28

Human Genetics

611
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
611
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

13.6K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
13.6K
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

103
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
103
CNS Depressants: Alcohol and Nicotine01:27

CNS Depressants: Alcohol and Nicotine

243
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
243

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patterns, Predictors, and Correlates of Problematic Alcohol Use and Remission From Adolescence to Early Midlife.

Alcohol, clinical & experimental research·2026
Same author

Bidirectional associations between cannabis use, oddball performance and P3 event-related potential.

medRxiv : the preprint server for health sciences·2026
Same author

Lifespan Trajectories of Resting State EEG power.

bioRxiv : the preprint server for biology·2026
Same author

Network and receptor architectures shape brain morphometry in addiction.

medRxiv : the preprint server for health sciences·2026
Same author

Multiplex Portuguese Families as a Lens into rare mutations and the Shared Genetic Architecture of Schizophrenia, Mood Disorders, and Autism Spectrum Disorders.

medRxiv : the preprint server for health sciences·2026
Same author

The 10-year stability of three subscale scores of the Self-Report of the Effects of Alcohol measure and their relationship to changes in drinking quantities over the same period.

Alcohol, clinical & experimental research·2026

Related Experiment Video

Updated: Jul 19, 2025

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
09:26

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

18.8K

The collaborative study on the genetics of alcoholism: Brain function.

Jacquelyn L Meyers1, Sarah J Brislin2, Chella Kamarajan1

  • 1Department of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, Brooklyn, New York, USA.

Genes, Brain, and Behavior
|August 17, 2023
PubMed
Summary
This summary is machine-generated.

The Collaborative Study on the Genetics of Alcoholism (COGA) uses brain imaging and genetic data to understand alcohol use disorder (AUD). Their findings link brain function variations to AUD risk and consequences across diverse populations.

Keywords:
EEGEROERPalcohol use disorderfamilygenomicsneurocognitiveneurodevelopmentneurophysiologyneuropsychological

More Related Videos

An Inexpensive, Scalable Behavioral Assay for Measuring Ethanol Sedation Sensitivity and Rapid Tolerance in Drosophila
07:28

An Inexpensive, Scalable Behavioral Assay for Measuring Ethanol Sedation Sensitivity and Rapid Tolerance in Drosophila

Published on: April 15, 2015

10.3K
Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

947

Related Experiment Videos

Last Updated: Jul 19, 2025

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
09:26

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

18.8K
An Inexpensive, Scalable Behavioral Assay for Measuring Ethanol Sedation Sensitivity and Rapid Tolerance in Drosophila
07:28

An Inexpensive, Scalable Behavioral Assay for Measuring Ethanol Sedation Sensitivity and Rapid Tolerance in Drosophila

Published on: April 15, 2015

10.3K
Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

947

Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Alcohol use disorder (AUD) arises from complex genetic, neural, and environmental interactions.
  • The Collaborative Study on the Genetics of Alcoholism (COGA) investigates brain function's role in AUD risk and outcomes.
  • Understanding lifespan impacts requires examining genetic and environmental influences on brain activity.

Purpose of the Study:

  • To review COGA's data collection methods and brain function measures.
  • To showcase the significance and contributions of COGA data to AUD research.
  • To highlight key findings on brain-related risk and resilience factors in AUD.

Main Methods:

  • Utilized noninvasive brain electrical activity recordings (e.g., EEG).
  • Employed comprehensive neuropsychological testing.
  • Collected longitudinal, multi-modal family data from a diverse cohort.

Main Results:

  • Identified genetic variations associated with brain functioning relevant to AUD.
  • Differentiated brain-related risk/resilience factors from AUD consequences.
  • Amassed extensive brain function data from over 9871 diverse participants.

Conclusions:

  • COGA data have significantly advanced the understanding of genomic risk in AUD.
  • Neurophysiological and neuropsychological data are crucial for disentangling AUD factors.
  • COGA findings provide valuable insights into AUD etiology and progression over the lifespan.