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The role of hepatitis B virus genome variations in HBV-related HCC: effects on host signaling pathways

Shahrzad Shoraka1,2, Seyed Mahdi Hosseinian3, Ayda Hasibi4

  • 1Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Frontiers in Microbiology
|August 17, 2023
PubMed

Insights

Hepatitis B virus (HBV) mutations impact hepatocellular carcinoma (HCC) development by altering cell signaling pathways. Understanding these variations is key to developing targeted therapies for this common liver cancer.

Area of Science:

  • Hepatology
  • Virology
  • Molecular Biology

Background:

  • Hepatocellular carcinoma (HCC) is a major global health concern, often linked to viral hepatitis infections.
  • Hepatitis B virus (HBV) causes over half of virus-related HCC cases, underscoring its critical role in liver cancer pathogenesis.
  • HBV-related HCC development is a complex process influenced by host, viral, and environmental factors.

Purpose of the Study:

  • To review the role of HBV in HCC progression.
  • To focus on how HBV genome variations affect HCC-related signaling pathways.
  • To enhance understanding of molecular pathogenesis and identify therapeutic targets for HBV-related HCC.

Main Methods:

  • Literature review focusing on HBV genome variations.
  • Analysis of studies linking HBV mutations to host cell signaling pathways.
  • Synthesis of information on the impact of viral genetic diversity on HCC development.

Main Results:

  • HBV genome mutations and proteins can dysregulate cell signaling pathways crucial for HCC development.
  • Different HBV mutants exhibit varying pathogenicity, disease progression, and treatment responses.
  • Specific HBV variations are associated with altered host signaling, contributing to HCC.

Conclusions:

  • Understanding the interplay between HBV genome variations and host signaling pathways is vital for elucidating HCC pathogenesis.
  • Identifying commonly dysregulated pathways in HBV-related HCC can lead to novel therapeutic strategies.
  • Targeting specific molecular mechanisms driven by HBV mutations may improve HCC treatment outcomes.

Keywords:
carcinomachronicgenotypehepatitishepatitis B virushepatocellularmutationsignal transduction

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