Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multiscale Dissolution Simulation of Particles from a Tablet in Dissolution Apparatus by Coupling Discrete Element with Lattice Boltzmann Methods.

Pharmaceutical research·2026
Same author

Evaluation of a Novel Flexible Cage System for C5-C6 Fixation: A Finite Element Study Against Conventional ACDF Implants.

Bioengineering (Basel, Switzerland)·2026
Same author

Compacted solid implant formulations for long-term buprenorphine delivery.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Editorial: Integrated diagnostics and biomarker discovery in endocrinology and biomedical sciences, volume II.

Frontiers in endocrinology·2025
Same author

Recent advances in polymer-based drug delivery systems for atopic dermatitis: enhancing therapeutic efficacy and outcomes.

Materials today. Bio·2025
Same author

Challenges and innovations in long-acting injectable formulations: can formulation design space be rationalized?

The Journal of pharmacy and pharmacology·2025

Related Experiment Video

Updated: Jul 19, 2025

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
12:48

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

Published on: December 27, 2013

65.4K

The Impact of Post-Processing Temperature on PLGA Microparticle Properties.

Andrew Otte1,2, Bong Kwan Soh3,4, Kinam Park3,5,6

  • 1Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA. aotte@purdue.edu.

Pharmaceutical Research
|August 17, 2023
PubMed
Summary

Post-treatment temperature significantly impacts biodegradable poly(lactide-co-glycolide) (PLGA) microparticle properties and drug release. Controlling this temperature is crucial for achieving desired drug delivery performance.

Keywords:
PLGAmorphologynaltrexonepost-treatmentresidual solventrisperidone

More Related Videos

Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization
10:06

Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization

Published on: September 2, 2022

1.9K
Fabrication of Anisotropic Polymeric Artificial Antigen Presenting Cells for CD8+ T Cell Activation
10:16

Fabrication of Anisotropic Polymeric Artificial Antigen Presenting Cells for CD8+ T Cell Activation

Published on: October 12, 2018

8.1K

Related Experiment Videos

Last Updated: Jul 19, 2025

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
12:48

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

Published on: December 27, 2013

65.4K
Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization
10:06

Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization

Published on: September 2, 2022

1.9K
Fabrication of Anisotropic Polymeric Artificial Antigen Presenting Cells for CD8+ T Cell Activation
10:16

Fabrication of Anisotropic Polymeric Artificial Antigen Presenting Cells for CD8+ T Cell Activation

Published on: October 12, 2018

8.1K

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Biodegradable poly(lactide-co-glycolide) (PLGA) microparticles are widely used for controlled drug delivery.
  • Risperidone and naltrexone are active pharmaceutical ingredients often formulated into microparticle systems.

Purpose of the Study:

  • To investigate the effect of post-treatment temperature on PLGA microparticle characteristics.
  • To determine how temperature influences the in vitro drug release profiles of risperidone and naltrexone loaded microparticles.

Main Methods:

  • PLGA microparticles loaded with risperidone or naltrexone were prepared using emulsification homogenization.
  • The post-treatment temperature of the ethanolic solution was varied between 10°C and 35°C.

Main Results:

  • Post-treatment temperature influenced particle morphology, residual solvent content, glass transition temperature, and drug loading.
  • A triphasic in vitro release was observed at lower temperatures, while higher temperatures resulted in a biphasic pattern with an increased release rate.
  • The observed effects were molecule-dependent, impacting drug release kinetics.

Conclusions:

  • Post-treatment temperature is a critical manufacturing parameter for PLGA microparticles.
  • Precise control over the post-treatment process is essential for reproducible drug product performance and desired formulation profiles.