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Objective Image Quality Comparison Between Brain-Dedicated PET and PET/CT Scanners.

Maria Teresa Gandia-Ferrero1, Irene Torres-Espallardo2,3, Begoña Martínez-Sanchis3

  • 1Biomedical Imaging Research Group (GIBI230), La Fe Health Research Institute (IIS La Fe), Avenida Fernando Abril Martorell, València, 46026, Spain. mteresa_gandia@iislafe.es.

Journal of Medical Systems
|August 17, 2023
PubMed
Summary

A new brain PET scanner (CMB) shows higher contrast and recovery but more noise than PET/CT. Despite minor differences in diagnosis prediction and SUVr values, CT-based attenuation correction improved CMB image similarity to PET/CT.

Keywords:
Attenuation correctionBrain dedicated PETImage analysisImage quality

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Area of Science:

  • Medical Imaging
  • Nuclear Medicine
  • Radiology

Background:

  • Clinical validation of novel brain PET systems is essential.
  • Comparing brain-dedicated PET (CMB) to whole-body PET/CT is crucial for assessing image quality.
  • Attenuation correction (AC) is critical for PET image quality, especially in systems without CT.

Purpose of the Study:

  • To clinically validate a new brain-dedicated PET system (CMB) by comparing its image quality to a whole-body PET/CT scanner.
  • To evaluate the impact of emission-based versus CT-based attenuation correction on CMB PET images.
  • To assess diagnostic agreement between the CMB and PET/CT scanners using a neural network.

Main Methods:

  • Acquisition of Hoffman phantom and patient data using both CMB and PET/CT scanners.
  • Evaluation of CMB PET images using both emission-based and CT-based attenuation maps.
  • Quantitative comparison using 34 image quality metrics and qualitative assessment via neural network for diagnostic prediction.

Main Results:

  • CMB images demonstrated higher contrast and recovery coefficients but also increased noise compared to PET/CT.
  • Statistically significant differences in SUVr values were observed in several brain regions, though relative differences were minimal.
  • CT-based AC in CMB yielded images more similar to PET/CT than emission-based AC, with minor overall variations between devices.

Conclusions:

  • The CMB system offers high contrast and recovery for brain imaging, comparable to PET/CT.
  • CT-based attenuation correction is superior for CMB image quality and consistency with PET/CT.
  • Despite minor observed differences, the CMB scanner shows potential for clinical brain imaging with reliable diagnostic performance.