Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Haptoglobin groups and lung cancer.

G Beckman, A Eklund, N Fröhlander

    Human Heredity
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Longitudinal and cross-sectional analysis of perfluoroalkyl substances and kidney function.

    Journal of exposure science & environmental epidemiology·2025
    Same author

    Variability of Normal Pressure Hydrocephalus Imaging Biomarkers with Respect to Section Plane Angulation: How Wrong a Radiologist Can Be?

    AJNR. American journal of neuroradiology·2021
    Same author

    Diagnosing Carotid Near-Occlusion with Phase-Contrast MRI.

    AJNR. American journal of neuroradiology·2021
    Same author

    Changes in lung immune cells related to clinical outcome during treatment with infliximab for sarcoidosis.

    Clinical and experimental immunology·2020
    Same author

    Can pulsatile CSF flow across the cerebral aqueduct cause ventriculomegaly? A prospective study of patients with communicating hydrocephalus.

    Fluids and barriers of the CNS·2019
    Same author

    Risk factors for pancreatitis following endoscopic retrograde cholangiopancreatography.

    BJS open·2019
    Same journal

    Comparative profiles of pediatric Mendeliome: A Single-Centre 572-Whole-Exome Sequencing Study in Xinjiang.

    Human heredity·2026
    Same journal

    Erratum.

    Human heredity·2026
    Same journal

    Exploratory Analysis of HMGB1 Genetic Variants and Their Potential Association with Lung Cancer Susceptibility and Chemotherapy Response in a Chinese Population.

    Human heredity·2025
    Same journal

    Weighted Burden Analysis of Rare Genetic Variants Identifies Novel Genes with Effects on BMI.

    Human heredity·2025
    Same journal

    Generalized Stable Population and Agent-Based Models of Phenotypic Transmission in Human Populations, with an Application to Body Size.

    Human heredity·2025
    Same journal

    Proteinase-activated receptor 2 (PAR-2) expression and F2RL1 genetic variants are associated with asthma: a case-control study in the Chinese population.

    Human heredity·2025
    See all related articles

    Haptoglobin (Hp) 2-2 type was less common in lung adenocarcinoma patients, particularly females. Hp 1-1 and Hp 2-1 types were more frequent in these patients compared to controls.

    Area of Science:

    • Genetics
    • Oncology
    • Biochemistry

    Background:

    • Haptoglobin (Hp) is a protein involved in hemoglobin binding.
    • Hp polymorphism has been linked to various diseases.
    • Its role in lung cancer, specifically adenocarcinoma, requires further investigation.

    Purpose of the Study:

    • To investigate the association between haptoglobin (Hp) phenotypes and primary lung cancer.
    • To determine if Hp genotype frequencies differ in lung cancer subtypes compared to controls.
    • To explore potential sex-specific differences in Hp phenotype distribution within adenocarcinoma patients.

    Main Methods:

    • Analysis of haptoglobin (Hp) phenotypes in 309 primary lung cancer patients.
    • Categorization of patients by sex, smoking habits, and tumor type (squamous epithelial, oat-cell, pulmonary adenocarcinoma).

    Related Experiment Videos

  • Comparison of Hp phenotype frequencies between patient groups and normal controls.

    • Main Results:

    • No significant difference in Hp phenotype distribution was observed for squamous epithelial or oat-cell lung cancers compared to controls.
    • Patients with pulmonary adenocarcinoma showed a significantly lower frequency of the Hp 2-2 type (p < 0.05) and a corresponding increase in Hp 1-1 and Hp 2-1 types.
    • This Hp phenotype shift in pulmonary adenocarcinoma was more pronounced in female patients (p < 0.025).

    Conclusions:

    • Haptoglobin (Hp) genotype may be associated with the risk or development of pulmonary adenocarcinoma.
    • The Hp 2-2 phenotype appears to be protective against pulmonary adenocarcinoma, especially in females.
    • Further research is warranted to elucidate the biological mechanisms underlying this association.