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Urinary Tract Infection in a Small Animal Model: Transurethral Catheterization of Male and Female Mice
Published on: December 1, 2017
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Immune defenses in the urinary tract
Hunter W Kuhn1, Teri N Hreha1, David A Hunstad2
1Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
Trends in Immunology
|August 17, 2023
Summary
Recent research highlights how the host
Area of Science:
- Immunology
- Microbiology
- Urology
Background:
- Urinary tract infections (UTIs) are common bacterial infections.
- Understanding the host response is crucial for managing UTIs.
- Preclinical models have advanced our knowledge of UTI pathogenesis.
Purpose of the Study:
- To review recent insights into host responses during UTIs.
- To discuss the roles of immune cells and molecules in controlling uropathogens.
- To explore novel therapeutic strategies for acute and recurrent UTIs.
Main Methods:
- Review of recent preclinical studies on UTI models.
- Analysis of host immune cell functions (neutrophils, macrophages).
- Examination of antimicrobial peptides and renal epithelial cell functions.
Main Results:
- Key host factors influencing pathogen clearance and tissue damage identified.
- Novel functions of neutrophils, macrophages, and antimicrobial peptides in innate defense elucidated.
- Epigenetic modifications linked to bladder remodeling and recurrent UTI susceptibility.
Conclusions:
- Contemporary research better defines host processes in UTI susceptibility and severity.
- New insights may guide the development of novel preventive and therapeutic approaches for UTIs.
- Further research into host-pathogen interactions is essential for combating acute and recurrent UTIs.
Keywords:
Escherichia coliantimicrobial peptidesepigenetic remodelinginnate immunitymacrophagesneutrophilspyelonephritisMore Related Videos
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