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Circulating tumor cell-derived preclinical models: current status and future perspectives.

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Circulating tumor cells (CTCs) are key to understanding cancer spread and developing new treatments. This review covers preclinical models, like CTC-derived xenografts, for studying CTCs and advancing precision cancer medicine.

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Area of Science:

  • Oncology
  • Translational Research
  • Cancer Biology

Background:

  • Metastasis is a leading cause of cancer mortality, with circulating tumor cells (CTCs) driving cancer dissemination.
  • CTCs, though rare in peripheral blood, are crucial for understanding metastatic mechanisms and developing advanced cancer therapies.
  • Research focuses on CTCs due to their accessibility and potential for unraveling cancer spread.

Purpose of the Study:

  • To review recent advancements in establishing preclinical models derived from CTCs.
  • To evaluate the utility of CTC-derived models for cancer research.
  • To discuss the potential of CTCs and their models in precision medicine and treatment decisions.

Main Methods:

  • Review of literature on preclinical models of circulating tumor cells (CTCs).
  • Focus on CTC-derived xenografts (CDX) and cell cultures as key experimental models.
  • Discussion of the advantages and limitations of current CTC-derived models.

Main Results:

  • CTC-derived xenografts (CDX) and cell cultures are promising preclinical models for studying CTCs.
  • These models facilitate a deeper understanding of cancer dissemination mechanisms.
  • Established models offer valuable tools for advancing cancer research.

Conclusions:

  • CTC-derived models are essential for studying metastasis and developing targeted therapies.
  • These models hold significant potential for informing cancer treatment decisions.
  • CTCs and their derived models are pivotal for the advancement of precision oncology tools.