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Antioxidants, Hormetic Nutrition, and Autism.
Sergio Modafferi1, Gabriella Lupo1, Mario Tomasello1
1Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, 950125, Italy.
Current Neuropharmacology
|August 18, 2023
Summary
Polyphenols from mushrooms may offer a novel therapeutic approach for autism spectrum disorder (ASD). These compounds activate cellular defense mechanisms, potentially improving neuroprotection and addressing redox imbalances in ASD.
Area of Science:
- Neuroscience
- Biochemistry
- Nutritional Science
Background:
- Autism spectrum disorder (ASD) is a complex neurodevelopmental condition marked by social-communication deficits and repetitive behaviors.
- Disturbed redox homeostasis is implicated in the pathology of ASD.
- Polyphenols exhibit neuroprotective effects and modulate cellular resilience.
Purpose of the Study:
- To explore the potential therapeutic role of mushroom-derived polyphenols in ASD.
- To discuss the mechanisms of action, including hormesis and modulation of Nrf2 and NF-κB pathways.
Main Methods:
- Review of existing literature on polyphenols, mushrooms, and neurodegenerative disorders.
- Focus on cellular resilience mechanisms and hormetic nutrients.
- Discussion of signaling pathways like Nrf2 and NF-κB.
Main Results:
- Nutritional mushrooms contain polyphenols with demonstrated protective effects in neurodegenerative models.
- Polyphenols can induce endogenous defense systems by modulating Nrf2 and NF-κB pathways.
- Hormesis, induced by low-level stressors, is a key mechanism.
Conclusions:
- Mushroom-derived polyphenols represent a promising avenue for ASD therapeutic strategies.
- Modulating cellular resilience through hormetic nutrients offers a novel approach.
- Targeting Nrf2 and NF-κB pathways is crucial for neuroprotection in ASD.
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