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Nifedipine compared with verapamil in unstable angina pectoris
International Journal of Clinical Pharmacology Research
|January 1, 1986
Summary
Both oral verapamil and nifedipine effectively reduce symptomatic ischemic episodes in unstable angina patients. This short-term treatment confirms their efficacy, though myocardial infarctions still occurred.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Unstable angina presents a significant clinical challenge.
- Effective short-term management of ischemic episodes is crucial.
Purpose of the Study:
- To compare the efficacy of oral verapamil versus nifedipine in unstable angina.
- To assess the reduction in symptomatic and asymptomatic ischemic episodes.
Main Methods:
- A randomized trial involving 22 unstable angina patients.
- Comparison of nifedipine (20 mg q6h) and verapamil (120 mg q6h) over 96 hours.
- Holter monitoring for asymptomatic episodes and coronary angiography.
Main Results:
- Both drugs significantly reduced daily symptomatic ischemic episodes (p<0.01).
- Both drugs significantly reduced total ischemic episodes (p<0.03).
- High short-term efficacy for both nifedipine and verapamil was confirmed.
Conclusions:
- Oral verapamil and nifedipine are highly effective in reducing ischemic episodes in unstable angina.
- Despite efficacy, a notable incidence of myocardial infarction occurred.
- Some patients required subsequent coronary bypass graft surgery.