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Research trends in cardiovascular tissue engineering from 1992 to 2022: a bibliometric analysis
Ping Lai1,2, Ming Sheng3, Jin-Hua Ye4
1Department of Cardiology, First Affiliated Hospital of Gannan Medical University, Gannan Medical University, Ganzhou, China.
Insights
Cardiovascular tissue engineering (CTE) research is rapidly growing, with the United States leading in publications and citations. Future directions include functional maturation and novel biomaterials for treating heart diseases.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Cardiovascular Research
Background:
- Cardiovascular tissue engineering (CTE) offers a promising approach for treating severe heart conditions like myocardial infarction.
- Despite extensive research over 30 years, a comprehensive analysis of CTE's status, trends, and future potential has been lacking.
- This bibliometric study aims to elucidate current trends and identify potential future research avenues in CTE.
Purpose of the Study:
- To analyze the research landscape of cardiovascular tissue engineering.
- To identify key trends, influential regions, and emerging research themes.
- To forecast potential future directions in the field of CTE.
Main Methods:
- A bibliometric analysis was conducted on publications from the Web of Science Core Collection up to August 5, 2022.
- Data analysis involved publication trends, research directions, and visual mapping using specialized software (Excel, VOSviewer, Citespace).
- Inclusion and exclusion criteria were applied to select relevant research articles and review papers.
Main Results:
- A total of 2,273 documents published between 1992 and 2022 were analyzed, showing a significant upward trend in publications.
- The United States emerged as the leading contributor in terms of publications, citations, and H-index.
- Key emerging keywords include 'functional maturation,' 'cell-derived cardiomyocytes,' 'composite scaffolds,' and 'maturation,' indicating active research areas.
Conclusions:
- Cardiovascular tissue engineering is a dynamic and highly active research field.
- The United States demonstrates a dominant position in CTE research output and impact.
- Future research should focus on functional maturation, novel biomaterials, and interdisciplinary collaborations for advancing CTE applications.
Background:
Cardiovascular tissue engineering (CTE) is a promising technique to treat incurable cardiovascular diseases, such as myocardial infarction and ischemic cardiomyopathy. Plenty of studies related to CTE have been published in the last 30 years. However, an analysis of the research status, trends, and potential directions in this field is still lacking. The present study applies a bibliometric analysis to reveal CTE research trends and potential directions.
Methods:
On 5 August 2022, research articles and review papers on CTE were searched from the Web of Science Core Collection with inclusion and exclusion criteria. Publication trends, research directions, and visual maps in this field were obtained using Excel (Microsoft 2009), VOSviewer, and Citespace software.
Results:
A total of 2,273 documents from 1992 to 2022 were included in the final analysis. Publications on CTE showed an upward trend from 1992 [number of publications (Np):1] to 2021 (Np:165). The United States (Np: 916, number of citations: 152,377, H-index: 124) contributed the most publications and citations in this field. Research on CTE has a wide distribution of disciplines, led by engineering (Np: 788, number of citations: 40,563, H-index: 105). "Functional maturation" [red cluster, average published year (APY): 2018.63, 30 times], "cell-derived cardiomyocytes" (red cluster, APY: 2018.43, 46 times), "composite scaffolds" (green cluster, APY: 2018.54, 41 times), and "maturation" (red cluster, APY: 2018.17, 84 times) are the main emerging keywords in this area.
Conclusion:
Research on CTE is a hot research topic. The United States is a dominant player in CTE research. Interdisciplinary collaboration has played a critical role in the progress of CTE. Studies on functional maturation and the development of novel biologically relevant materials and related applications will be the potential research directions in this field.
