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Recent advancements in pharmacological strategies to modulate energy balance for combating obesity

Benudhara Pati1, Satyabrata Sendh1, Bijayashree Sahu1

  • 1School of Biotechnology, KIIT University Bhubaneswar Odisha 751024 India naresh.bal@kiitbiotech.ac.in.

RSC Medicinal Chemistry
|August 18, 2023
PubMed

Insights

Obesity and metabolic diseases are rising globally. Pharmacological approaches, including nonshivering thermogenesis (NST) activators and combination therapies, show promise for effective anti-obesity drug development.

Area of Science:

  • Metabolic Science
  • Pharmacology
  • Obesity Research

Background:

  • Global rise in obesity and related metabolic diseases.
  • Genetic, behavioral, and environmental factors complicate obesity.
  • Limited success of lifestyle interventions necessitates pharmacological solutions.

Purpose of the Study:

  • Review anti-obesity drug development strategies.
  • Evaluate current and emerging pharmacological targets.
  • Identify promising future therapeutic approaches.

Main Methods:

  • Compilation of scientific articles, magazines, newspapers, and online resources.
  • Analysis of mechanisms targeting energy intake and expenditure.
  • Assessment of drug development strategies, including nonshivering thermogenesis (NST).

Main Results:

  • Current drugs primarily reduce energy intake; some metabolic targeting shows toxicity.
  • Nonshivering thermogenesis (NST) offers a selective approach with fewer side effects.
  • Combination therapy of metabolic boosters and existing anti-obesity drugs is a promising avenue.

Conclusions:

  • Pharmacological interventions are crucial for combating the obesity epidemic.
  • Targeting nonshivering thermogenesis (NST) presents a viable strategy.
  • Further research into combination therapies is essential for advancing anti-obesity drug development.

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