Structural mechanisms of postlesional remodelling in the central nervous system

Numerous recent experimental studies have evidenced that considerable remodelling takes place in the central nervous system following an injury. The postlesional reorganization is particularly active in the central circuits when the injury occurs during development. The basic structural postlesional mechanisms, such as axonal sprouting and synaptic rearrangement, are here briefly outlined. Experimental evidence of postlesional structural reorganization of central neurons is provided, with special reference to the remodelling that follows cerebellar lesions.