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Updated: Jul 19, 2025

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Cyclic Sulfinamides.
Alexey V Dobrydnev1,2, Maria V Popova1,3, Yulian M Volovenko1
1Taras Shevchenko National University of Kyiv, Volodymyrska Street 60, Kyiv, 01033, Ukraine.
This review summarizes cyclic sulfinamides (sultims) from 1989-2022, detailing their synthesis, chemical properties, reactions, and applications. It provides insights for synthetic organic and pharmaceutical chemists.
Area of Science:
- Organic Chemistry
- Medicinal Chemistry
Background:
- Cyclic sulfinamides, also known as sultims, are versatile heterocyclic compounds.
- A comprehensive review of sultim literature from 1989 to 2022 is presented.
Purpose of the Study:
- To provide a detailed overview of the synthetic methodologies for preparing sultims.
- To discuss the chemical properties, reactions, and applications of sultims.
Main Methods:
- Literature review and analysis of published research on sultims.
- Detailed examination of reaction conditions and mechanisms.
Main Results:
- Compilation of diverse synthetic routes to sultims.
- Exploration of sultim reactivity and utility in various chemical transformations.
Conclusions:
- Sultims are valuable building blocks in organic synthesis.
- This review serves as a key resource for researchers in synthetic and pharmaceutical chemistry.
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