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Related Concept Videos

Inhaled Medications01:23

Inhaled Medications

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Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
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Inhalation powder development without carrier: How to engineer ultra-flying microparticles?

Anna Lechanteur1, Eva Gresse1, Luisa Orozco2

  • 1Laboratory of Pharmaceutical Technology and Biopharmacy, CIRM, University of Liège, Liège 4000, Belgium.

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PubMed
Summary
This summary is machine-generated.

Optimized spray drying created new inhaled powders for asthma, achieving over 55% fine particle fraction for superior deep lung drug delivery compared to existing products.

Keywords:
DOEDPIInhalationParticle engineeringSpray drying

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Area of Science:

  • Pharmaceutical Technology
  • Drug Delivery Systems
  • Respiratory Medicine

Background:

  • Particle engineering enables advanced inhaled powders like PulmoSol™ and PulmoSphere™.
  • Spray drying is a versatile technique for producing inhalable powders with tunable properties.
  • Optimizing low-dose formulations is crucial for effective asthma management.

Purpose of the Study:

  • To optimize the production of low-dose inhaled powders containing budesonide and formoterol.
  • To maximize deep lung deposition of anti-asthmatic drugs using spray drying.
  • To investigate the impact of excipients and process parameters on powder performance.

Main Methods:

  • Utilized a Design of Experiments (DOE) approach to systematically vary formulation and process parameters.
  • Produced 27 different powder batches with varying excipient mixes (cyclodextrins, raffinose, maltodextrins), concentrations, and spray drying conditions.
  • Evaluated deep lung deposition using fine particle fraction (FPF) measurements with a next-generation impactor.

Main Results:

  • Two optimized powders, one using hydropropyl-β-cyclodextrin and another with a blend including L-leucine, achieved FPF exceeding 55%.
  • These FPF values significantly outperformed currently available commercial products.
  • Deep lung deposition correlated with reduced particle size and lower inter-particular interactions, confirmed by laser diffraction and morphometry.

Conclusions:

  • Developed novel carrier-free inhalation powders with highly efficient lung deposition capabilities.
  • Demonstrated that inter-particular interactions significantly influence aerosolization behavior and drug delivery efficiency.
  • The optimized powders promise uniform drug distribution in the lungs, essential for effective asthma symptom control.