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Association between thyroid function and diabetes peripheral neuropathy in euthyroid type 2 diabetes mellitus
Qingyuan He1, Zekun Zeng1, Man Zhao1,2
1Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
Scientific Reports
|August 18, 2023
Summary
Lower free thyroxine (FT4) levels are linked to a higher risk of diabetic peripheral neuropathy (DPN) in euthyroid type 2 diabetes mellitus (T2DM) patients. This finding highlights the importance of monitoring thyroid function in T2DM management.
Area of Science:
- Endocrinology
- Neurology
- Metabolic Diseases
Background:
- Subclinical hypothyroidism (SCH) and high thyroid stimulating hormone (TSH) are known risk factors for diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus (T2DM).
- The impact of thyroid function on DPN in euthyroid T2DM patients remains unclear.
Purpose of the Study:
- To investigate the association between thyroid function and DPN in euthyroid T2DM patients.
- To identify potential thyroid-related biomarkers for DPN risk in this population.
Main Methods:
- Cross-sectional study of 580 euthyroid T2DM patients, stratified into DPN and Non-DPN groups.
- Statistical analyses included Mann-Whitney U test, Chi-square test, Spearman correlation, and logistic regression.
- Patients were categorized into quartiles based on free thyroxine (FT4) levels to assess DPN prevalence.
Main Results:
- Euthyroid T2DM patients with DPN exhibited significantly lower levels of FT4 and various biochemical markers compared to those without DPN.
- FT4 levels showed significant correlations with multiple clinical indicators, including total protein, albumin, and lipids.
- A negative correlation was observed between FT4 levels and DPN prevalence, with the lowest FT4 quartile showing the highest DPN risk.
Conclusions:
- Reduced free thyroxine (FT4) levels are associated with an increased prevalence and risk of diabetic peripheral neuropathy (DPN) in euthyroid type 2 diabetes mellitus (T2DM) patients.
- Thyroid function, specifically FT4 levels, may play a role in the development of DPN in euthyroid T2DM individuals.
- Monitoring FT4 may be beneficial for assessing DPN risk in euthyroid T2DM patients.
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