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Genes, environment, and African ancestry in cardiometabolic disorders

Ayo P Doumatey1, Amy R Bentley1, Rufus Akinyemi2

  • 1Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Trends in Endocrinology and Metabolism: TEM
|August 19, 2023
PubMed

Insights

Cardiometabolic diseases disproportionately affect African ancestry populations. Increased inclusion in genomics research is crucial for understanding disease drivers and advancing precision medicine for these groups.

Area of Science:

  • Cardiology
  • Genetics
  • Public Health

Background:

  • Global rise in cardiometabolic diseases over the past two decades.
  • Significant disparities in disease prevalence and incidence across populations.
  • African ancestry populations are disproportionately affected but under-represented in research.

Purpose of the Study:

  • Discuss cardiometabolic diseases and traits in populations of African descent.
  • Highlight genetic and environmental contributors to these conditions.
  • Review initiatives to increase African descent inclusion in genomics research.

Main Methods:

  • Literature review and synthesis of current research on cardiometabolic diseases in African populations.
  • Analysis of genetic and environmental factors influencing disease presentation.
  • Examination of ongoing and proposed genomic initiatives.

Main Results:

  • African ancestry populations exhibit significant genetic and environmental diversity.
  • Under-representation in research leads to missed discoveries and exacerbates health disparities.
  • Novel discoveries are emerging from focused research efforts.

Conclusions:

  • Addressing the under-representation of African descent populations in genomics is critical.
  • Equitable precision medicine requires inclusive research strategies.
  • New initiatives aim to bridge current gaps in genomic data for these populations.

Keywords:
African ancestrycardiometabolic diseaseepidemiologygene and environment interactionslifestyle

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