Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Preclinical Development: Overview01:28

Preclinical Development: Overview

4.5K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
4.5K
Clinical Trials: Overview01:11

Clinical Trials: Overview

3.0K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
3.0K
Clinical Trials01:16

Clinical Trials

6.8K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
6.8K
Nursing Clinical Information System01:27

Nursing Clinical Information System

813
Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
813

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of antibiotic prophylaxis courses on postoperative complications following total joint arthroplasty: Finding from Chinese population.

Journal of clinical pharmacy and therapeutics·2021
Same author

Time-course alterations of gut microbiota and short-chain fatty acids after short-term lincomycin exposure in young swine.

Applied microbiology and biotechnology·2021
Same author

Collaborative Assessment and Health Risk of Heavy Metals in Soils and Tea Leaves in the Southwest Region of China.

International journal of environmental research and public health·2021
Same author

Trends of Antibiotic Use and Expenditure After an Intensified Antimicrobial Stewardship Policy at a 2,200-Bed Teaching Hospital in China.

Frontiers in public health·2021
Same author

PDZ Binding Kinase/T-LAK Cell-Derived Protein Kinase Plays an Oncogenic Role and Promotes Immune Escape in Human Tumors.

Journal of oncology·2021
Same author

Construction of a Polarity-Switchable Photoelectrochemical Biosensor for Ultrasensitive Detection of miRNA-141.

Analytical chemistry·2021
Same journal

An IL-15 fusion with albumin-binding domain boosts Immunotherapy therapy in glioblastoma via FGF-2 competition regulating FGFR1/2.

Cancer letters·2026
Same journal

Stress-adapted cancer-associated fibroblasts as mediators of immunosuppression and therapy resistance.

Cancer letters·2026
Same journal

Aldo-keto Reductase Family 1 Member C3 Suppresses Glioma Progression via Inhibiting Prostaglandin D2-Dependent RhoA/ROCK Signaling.

Cancer letters·2026
Same journal

Immunotherapy-based combination remodels the immunosuppressive microenvironment and enhances efficacy in advanced SMARCA4-deficient non-small cell lung cancer.

Cancer letters·2026
Same journal

Early-onset lung cancer: etiologic heterogeneity, genomic features, and age-informed clinical management.

Cancer letters·2026
Same journal

Talazoparib engages innate immune activation via PARP trapping-dependent cGAS/STING activation in Ewing Sarcoma.

Cancer letters·2026
See all related articles

Related Experiment Video

Updated: Jul 18, 2025

Author Spotlight: Advancing Personalized Medicine in Ovarian Cancer
08:26

Author Spotlight: Advancing Personalized Medicine in Ovarian Cancer

Published on: February 23, 2024

2.0K

Organoid: Bridging the gap between basic research and clinical practice.

Guihu Weng1, Jinxin Tao1, Yueze Liu1

  • 1Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan, Wangfujing Street, Beijing, 100730, China.

Cancer Letters
|August 20, 2023
PubMed
Summary
This summary is machine-generated.

Organoid models offer a promising future for personalized cancer medicine, improving tumor research and clinical applications. This review explores their role in advancing precision oncology and suggests future directions for organoid platform development.

Keywords:
Clinical decision-makingMicrobes-host interactionNew generation of organoid platformOrganoidRegenerative strategyTumor biology

More Related Videos

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
07:46

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

4.8K
Ovarian Cancer Patient-Derived Organoid Models for Pre-Clinical Drug Testing
05:35

Ovarian Cancer Patient-Derived Organoid Models for Pre-Clinical Drug Testing

Published on: September 15, 2023

1.6K

Related Experiment Videos

Last Updated: Jul 18, 2025

Author Spotlight: Advancing Personalized Medicine in Ovarian Cancer
08:26

Author Spotlight: Advancing Personalized Medicine in Ovarian Cancer

Published on: February 23, 2024

2.0K
Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
07:46

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

4.8K
Ovarian Cancer Patient-Derived Organoid Models for Pre-Clinical Drug Testing
05:35

Ovarian Cancer Patient-Derived Organoid Models for Pre-Clinical Drug Testing

Published on: September 15, 2023

1.6K

Area of Science:

  • Oncology
  • Regenerative Medicine
  • Translational Medicine

Background:

  • Current tumor models inadequately support precise and personalized cancer diagnosis and treatment.
  • Organoid platforms are emerging as powerful tools with significant potential in basic-translational medicine.

Purpose of the Study:

  • To explore the pivotal role of organoid models in basic research and clinical practice.
  • To highlight organoid applications in tumor biology, microbe-host interactions, clinical decision-making, and regenerative strategies.
  • To propose strategies for developing advanced organoid platforms.

Main Methods:

  • Review of existing literature on organoid models in cancer research.
  • Analysis of organoid applications across various aspects of oncology.
  • Discussion on the future development of organoid technology.

Main Results:

  • Organoid platforms demonstrate unique advantages for studying tumor biology and tumorigenic microbes-host interactions.
  • Organoids show potential in enhancing clinical decision-making and guiding regenerative strategies.
  • The development of next-generation organoid platforms is crucial for advancing personalized medicine.

Conclusions:

  • Organoid models are poised to revolutionize personalized cancer care by bridging basic research and clinical practice.
  • Further innovation in organoid platform construction will accelerate progress in precision oncology and translational medicine.