A two-step access to fused-/spiro-polycyclic frameworks via double Heck cascade and acid-driven processes
Komal Goel1, Gedu Satyanarayana1
1Department of Chemistry, Indian Institute of Technology (IIT), Hyderabad, Kandi, Sangareddy - 502285, India. gvsatya@iith.ac.in.
Abstract:
This report illustrates the rapid construction of two divergent classes of polycyclic frameworks, benzo[a]fluorenones and spiro-chromenone indenes, via a double Heck cascade and an acid-driven cyclization from easily accessible precursors, alkyl 2-bromocinnamate esters and diphenylacetylenes. The present strategy has surveyed a broad substrate scope and delivered an array of products with interesting structural features. Besides, fluorescence studies were performed for the synthesized benzo[a]fluorenones.
Related Concept Videos
Cycloaddition Reactions: Overview
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction
Acid-Catalyzed Ring-Opening of Epoxides
Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry
Cationic Chain-Growth Polymerization: Mechanism
Ziegler–Natta Chain-Growth Polymerization: Overview

![Solid-phase Synthesis of [4.4] Spirocyclic Oximes](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58508.jpg&w=3840&q=50)
