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Updated: Jul 18, 2025
Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Synthesis, crystal structure and Hirshfeld surface analysis of bis-(caffeinium) hexa-chlorido-platinum(IV) in
Karim A Zagidullin1, Anton P Novikov1,2, Daria A Zelenina1,3
1Frumkin Institute of Physical Chemistry and Electrochemistry Russian, Academy, of Sciences, 31 Leninsky Prospekt bldg 4, 119071 Moscow, Russian Federation.
Abstract:
The mol-ecular and crystal structure of the title compound, (C8H11N4O2)2[PtCl6], synthesized from hexa-chloro-platinic acid and caffeine in methanol, was studied by single-crystal X-ray diffraction. The caffeinium cations form a double layer via hydrogen bonds and π-stacking inter-actions. The Hirshfeld surface analysis showed that the largest contribution to the crystal packing is made by H⋯H (31.2%), H⋯Cl/Cl⋯H (22.6%), O⋯H/H⋯O (21.9%) contacts for the cation and H⋯Cl/Cl⋯H (79.3%) contacts for the anion.
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