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ADIPONECTIN LEVELS IN GRAVES' DISEASE - SYSTEMATIC REVIEW AND META-ANALYSIS.

A Ismaiel1, A L Abunahleh2, A Elsayed3

  • 1"Iuliu Hațieganu" University of Medicine and Pharmacy, 2 Department of Internal Medicine, Cluj-Napoca, Ireland.

Acta Endocrinologica (Bucharest, Romania : 2005)
|August 21, 2023
PubMed
Summary
This summary is machine-generated.

This study found higher adiponectin levels in Graves' disease patients compared to controls and hypothyroidism. Adiponectin levels did not significantly differ in Graves' ophthalmopathy patients.

Keywords:
Graves' diseaseadipokinesadiponectinendocrinologyhyperthyroidism

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Area of Science:

  • Endocrinology
  • Metabolic Disorders
  • Molecular Biology

Background:

  • Graves' disease is a leading cause of hyperthyroidism globally.
  • Adiponectin, an abundant adipokine, is linked to metabolic disorders.
  • Previous studies on adiponectin and Graves' disease show inconsistent results.

Purpose of the Study:

  • To systematically review and meta-analyze the association between adiponectin levels and Graves' disease.

Main Methods:

  • Systematic electronic search of PubMed, EMBASE, Scopus, and Cochrane Library.
  • Quality assessment of included studies using NHLBI tools.
  • Qualitative synthesis of 11 studies (781 subjects) and quantitative synthesis of 6 studies.

Main Results:

  • Adiponectin levels were significantly elevated in Graves' disease patients versus controls (MD 2.983 [95% CI 0.138-5.828]).
  • Adiponectin levels were significantly higher in Graves' disease patients compared to hypothyroidism patients (MD 3.389 [95% CI 1.332-5.446]).
  • No significant difference in adiponectin levels was found between Graves' disease patients with and without Graves' ophthalmopathy.

Conclusions:

  • Adiponectin levels are significantly higher in individuals with Graves' disease.
  • Elevated adiponectin in Graves' disease may indicate a role in the condition's pathophysiology.
  • Adiponectin levels do not appear to correlate with the presence of Graves' ophthalmopathy.