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Large Animal Models of Cardiovascular Disease: From Training to Translation
Claudia Báez-Díaz1, Verónica Crisóstomo2
1Cardiovascular Area, Jesús Usón Minimally Invasive Surgery Centre, CIBERCV.
Journal of Visualized Experiments : Jove
|August 21, 2023
Summary
Large animal models, including swine and sheep, are crucial for cardiovascular disease research and training. These models enable the study of aneurysms, myocardial infarction, and atrial fibrillation, advancing medical understanding and treatment strategies.
Area of Science:
- Cardiovascular Research
- Animal Models
- Surgical Techniques
Background:
- Large animal models, particularly swine and sheep, are increasingly utilized for studying complex cardiovascular diseases.
- These models offer physiological similarities to humans, making them valuable for preclinical research and surgical training.
Discussion:
- Specific studies highlight the use of swine models for aneurysmal diseases and myocardial infarction induction via percutaneous techniques.
- Sheep models are employed for transcatheter pulmonary valve replacement using autologous pericardium and nitinol stents.
- Aachener minipigs serve as a model for sterile pericarditis, relevant to atrial myopathy and atrial fibrillation.
Key Insights:
- Swine models are effective for simulating aneurysms and induced myocardial infarction.
- Sheep models facilitate research into transcatheter valve replacement procedures.
- Minipig models provide insights into atrial fibrillation and related pathologies.
Outlook:
- Continued development and refinement of large animal models are essential for advancing cardiovascular medicine.
- These models will play a vital role in training surgeons and validating novel therapeutic interventions.
- Further research using these models promises to improve patient outcomes for a range of cardiac conditions.
