Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hormonal Regulation of the Menstrual Cycle

Hormonal Regulation of the Menstrual Cycle

The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...

Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents

Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents

The gastric mucosa produces prostaglandins E2 (PGE2) and prostacyclin (PGI2), crucial in maintaining gastric health. They exert cytoprotective effects, including increasing bicarbonate secretion, releasing protective mucin, reducing gastric acid output, and preventing harmful vasoconstriction. These effects are mediated through various receptors, such as EP1, EP2, EP3, and EP4.
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

CEACAM1 participation in breast cancer progression.

Molecular oncology·2026

Same author

The emergence of Clade IIb and Ib mpox viruses: a state-of-the-art review.

Annals of medicine and surgery (2012)·2026

Same author

Neurological complications post aortic arch surgery: a state of art review.

Journal of cardiothoracic surgery·2025

Same author

Gene editing for inherited cardiac conditions: A new frontier in cardiology.

Trends in cardiovascular medicine·2025

Same author

Potential of MRNA vaccines for mpox prevention: current evidence and future directions.

Annals of medicine and surgery (2012)·2025

Same author

Microgravity-induced alterations in the molecular and cellular characteristics of brain tumors: a systematic review.

Annals of medicine and surgery (2012)·2025

Search research articles

Related Experiment Video

Updated: Jul 18, 2025

Establishing 3D Endometrial Organoids from the Mouse Uterus

Establishing 3D Endometrial Organoids from the Mouse Uterus

Published on: January 6, 2023

ER and COX2 expression in endometrial hyperplasia processes.

Nataliia Tsyndrenko¹, Mykola Lyndіn^1,2, Kateryna Sikora¹

¹Sumy State University, Sumy, Ukraine.

|August 21, 2023

Summary

Endometrial hyperplasia and polyps show higher COX2 expression. Estrogen Receptor (ER) and COX2 expression correlate in the endometrium, suggesting a role in endometrial hyperplastic processes.

More Related Videos

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea

Published on: December 23, 2022

Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens

Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens

Published on: May 23, 2014

Related Experiment Videos

Last Updated: Jul 18, 2025

Establishing 3D Endometrial Organoids from the Mouse Uterus

Establishing 3D Endometrial Organoids from the Mouse Uterus

Published on: January 6, 2023

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea

Published on: December 23, 2022

Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens

Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens

Published on: May 23, 2014

Area of Science:

Gynecology
Pathology
Oncology

Background:

Endometrial hyperplastic processes (EHPs) include endometrial hyperplasia (EH) and endometrial polyps.
These conditions involve increased endometrial glands relative to stroma.

Purpose of the Study:

Investigate Estrogen Receptor (ER) and Cyclooxygenase-2 (COX2) expression in EH and endometrial polyps.
Determine correlations between ER/COX2 and histological/anthropometric parameters.

Main Methods:

Tissue samples from hysteroresectoscopy categorized into non-atypical EH, glandular EP, and glandular-fibrous EP.
Immunohistochemical analysis using anti-COX2 and anti-ER antibodies.

Main Results:

EHPs showed significantly higher COX2 expression than intact tissues.
A direct correlation between ER and COX2 expression was observed in endometrial epithelium.
No association found between ER/COX2 expression and EHP type or patient anthropometry.

Conclusions:

Varied ER and COX2 expressions in EHPs suggest synergistic involvement in initiation and progression.
These factors may play a role in endometrial hyperplastic processes and subsequent tumor transformation.