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CEACAM1 participation in breast cancer progression
Mykola Lyndin1,2, Irina Kube-Golovin1, Anatolii Romaniuk2
1Department of Anatomy, University Hospital Essen, Essen, Germany.
Molecular Oncology
|July 10, 2026
Summary
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) long isoform (CEACAM1-4L) suppresses breast cancer cell proliferation. This isoform regulates key pathways, suggesting diagnostic and therapeutic potential for invasive breast cancer (BC).
Area of Science:
- Oncology
- Molecular Biology
- Cell Biology
Background:
- Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is expressed in human cells and changes during cancer development.
- Its specific role in invasive breast cancer (BC) and its isoforms' functions are not fully understood.
Purpose of the Study:
- To analyze CEACAM1 expression in invasive BC tissues and correlate it with tumor cell proliferation.
- To investigate the isoform-specific functional effects of CEACAM1 and identify its target genes in proliferation pathways.
Main Methods:
- Analysis of CEACAM1 expression patterns in invasive BC tissues.
- In vitro transfection of MCF-7 cells with CEACAM1-4S and CEACAM1-4L isoforms.
- Transcriptome and protein-level analyses to identify CEACAM1-responsive genes.
Main Results:
- CEACAM1 expression showed heterogeneity in BC tissues, correlating with the tumor proliferative index (PI).
- The CEACAM1-4L isoform was found to suppress cell proliferation.
- CEACAM1-4L regulates genes involved in cell cycle, apoptosis, extracellular matrix organization, and growth factor signaling.
Conclusions:
- The CEACAM1-4L isoform plays a significant role in breast cancer biology.
- CEACAM1-4L may have diagnostic relevance for patient stratification in BC.
- CEACAM1-4L could be a potential target for future breast cancer therapies.
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