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Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
423
Epigenetics behind tumor immunology: a mini review
Martina Musella1, Nicoletta Manduca1, Ester Maccafeo1
1Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, 00168, Rome, Italy.
Oncogene
|August 21, 2023
Summary
Cancer immunotherapies show promise but face resistance. Combining them with epigenetic therapy, which targets cancer and immune cells, offers a strategy to overcome this resistance and improve treatment outcomes.
Area of Science:
- Oncology
- Immunology
- Epigenetics
Background:
- Immunotherapies and immune-based therapies are crucial in cancer treatment but often encounter innate or acquired resistance.
- Targeting immune inhibitory signals is essential for overcoming treatment resistance.
- Epigenetic therapy is emerging as a promising combination strategy due to its influence on cancer and immune cells within the tumor microenvironment.
Approach:
- This review details epigenetic dysregulations in cancer.
- Focuses on epigenetic alterations impacting innate immune signaling and Type I interferons.
- Highlights the translation of epigenetic knowledge into clinical treatment strategies.
Key Points:
- Epigenetic modifications play a significant role in cancer development and immune evasion.
- Specific epigenetic dysregulations affect innate immunity and the efficacy of Type I interferons.
- Combining epigenetic therapy with immunotherapy can potentially enhance anti-tumor immune responses.
Conclusions:
- Epigenetic therapy holds potential as a combination partner for cancer immunotherapies.
- Understanding epigenetic dysregulations offers new avenues for overcoming treatment resistance.
- Translating epigenetic insights into clinical practice may lead to improved patient outcomes in cancer treatment.
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