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The impact of obstructive sleep apnea in children with sickle cell disease and asthma

Lance Feld1, Anita Bhandari1,2, Julian Allen1,2

  • 1Division of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Pediatric Pulmonology
|August 22, 2023
PubMed

Insights

Children with sickle cell disease (SCD) and asthma may have a higher risk of obstructive sleep apnea (OSA). Screening for sleep-disordered breathing is recommended for routine care in these children.

Area of Science:

  • Pediatric Pulmonology
  • Hematology
  • Sleep Medicine

Background:

  • Asthma and obstructive sleep apnea (OSA) are chronic conditions impacting children with sickle cell disease (SCD).
  • The combined effect of OSA and asthma in children with SCD is not well-defined.
  • This study investigates the association between OSA and specific markers in children with SCD and asthma.

Purpose of the Study:

  • To determine if OSA in children with SCD and asthma is linked to distinct hematologic markers.
  • To assess the relationship between OSA and clinical outcomes in this population.
  • To evaluate healthcare utilization in asthmatic children with SCD and OSA.

Main Methods:

  • Retrospective evaluation of children with both SCD and asthma who underwent polysomnography (PSG).
  • Assessment of demographic data, PSG findings, hematologic indices, and healthcare utilization.
  • Comparison between children with and without concurrent OSA.

Main Results:

  • OSA was present in 59% of the cohort, associated with lower oxygen saturation nadir and daytime SpO2.
  • Children with OSA were more likely to have hemoglobin SS genotype and higher mean corpuscular volume and reticulocyte count.
  • No significant differences in asthma severity or healthcare utilization were observed between groups.

Conclusions:

  • Children with SCD and asthma may have an increased susceptibility to developing OSA.
  • Routine screening for sleep-disordered breathing is advisable for children with SCD and asthma.
  • Further research may elucidate specific management strategies for this patient group.
Abstract

Keywords:
asthmaobstructive sleep apneasickle cell disease

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