Electron Donor-Acceptor Complex Induced Fused Indoles with Hypervalent Iodine(III) Reagents
Li Liu1, Yage Zhang1, Wenyan Zhao1
1School of Pharmacy, Analysis and Testing Center, NERC Biomass of Changzhou University, Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, Changzhou University, Changzhou, 213164, China.
Abstract:
An operationally simple and efficient method for the cyclization of tertiary amines and hypervalent iodine reagents enabled by an EDA complex has been developed. A series of [1,2-α]indoles derivatives were obtained in good yields, including some key intermediates for the synthesis of biologically active molecules. In addition, this established strategy features a broad substrate scope and good functional group tolerance.
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