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An Ultrasound Array of Emitter-Receiver Stacks for Microbubble-Based Therapy.

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    Summary
    This summary is machine-generated.

    This study introduces a novel therapeutic ultrasound device using stacked emitter-receiver elements. This design overcomes trade-offs in traditional systems, enhancing both treatment safety and efficacy for short-pulse ultrasound applications.

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    Area of Science:

    • Biomedical Engineering
    • Acoustics
    • Medical Devices

    Background:

    • Traditional therapeutic ultrasound systems face a trade-off between emission efficiency and reception sensitivity due to separate emitter and receiver placements.
    • This limitation impacts the effectiveness and safety of procedures using long therapeutic pulses.

    Purpose of the Study:

    • To develop a novel therapeutic ultrasound array that overcomes the limitations of traditional designs by integrating emitters and receivers.
    • To enable effective short-pulse ultrasound therapy by enabling simultaneous emission and reception from the same location.

    Main Methods:

    • Developed a multi-element array using stacked lead zirconate titanate (PZT) emitters and polyvinylidene fluoride (PVDF) receivers.
    • Assembled 32 emitter-receiver elements into a 3D-printed dome-shaped frame with a 150 mm focal length.
    • Tested the array's performance in free-field and through an ex-vivo human skull, measuring peak-negative pressure and electronic steering capabilities.

    Main Results:

    • The array achieved a focal size of 4.5 × 4.5 × 32 mm in free-field, producing a peak-negative pressure (PNP) of 2.12 MPa.
    • Demonstrated electronic steering capabilities of ±15 mm laterally and >±15 mm axially.
    • Successfully produced a PNP of 0.63 MPa through an ex-vivo human skull and localized microbubble emissions.

    Conclusions:

    • The developed stacked emitter-receiver array effectively overcomes traditional trade-offs in therapeutic ultrasound devices.
    • This technology represents a significant advancement for short-pulse and microbubble-based therapeutic ultrasound applications.
    • The novel design has the potential to substantially improve the safety and efficacy of ultrasound treatments.