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Automatic Skull-Template Alignment Without a Guidance Image.

Oscar Bates1, Carlos Cueto1, Ciaran Coleman2

  • 1Department of Earth Science and Engineering, Imperial College London, London, UK; Sonalis Imaging Limited, London, UK.

Ultrasound in Medicine & Biology
|June 6, 2026
PubMed
Summary
This summary is machine-generated.

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Manifold optimization for full-waveform inversion (MOFI) enables accurate skull template registration for transcranial ultrasound without MRI. This method reduces barriers to clinical adoption of ultrasound imaging and therapy.

Area of Science:

  • Medical Imaging
  • Acoustic Physics
  • Computational Anatomy

Background:

  • Transcranial ultrasound applications are limited by the skull's acoustic distortions.
  • Accurate skull templates and spatial alignment are crucial for high-fidelity ultrasound simulations.
  • Current MRI-guided registration methods present significant financial and logistical challenges.

Purpose of the Study:

  • To develop a novel method for registering skull templates without requiring a guidance image.
  • To overcome the limitations of MRI-guided registration in transcranial ultrasound applications.

Main Methods:

  • Manifold optimization for full-waveform inversion (MOFI) was developed.
  • MOFI aligns skull templates by minimizing the difference between simulated and observed radiofrequency acoustic data.
Keywords:
Full-waveform inversion (FWI)Guidance-free registrationNeuroimagingTranscranial ultrasoundUltrasound tomography

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  • No concurrent imaging like MRI is needed for registration.

    • Main Results:

    • MOFI accurately recovers skull template positions in both in silico and in vitro settings.
    • The method provides a viable alternative to MRI-guided registration.
    • Successful registration was achieved without the need for a guidance image.

    Conclusions:

    • MOFI offers a practical, MRI-free approach for transcranial ultrasound registration.
    • This technique has the potential to reduce barriers to clinical adoption.
    • MOFI can facilitate wider use of transcranial ultrasound for imaging and therapy.