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Development of Cell-Derived Plasma Membrane Vesicles as a Nanoparticle Encapsulation and Delivery System.
Biorxiv : the Preprint Server for Biology
|August 23, 2023
Summary
Giant plasma membrane vesicles (GPMVs) efficiently encapsulate nanoparticles, improving cellular delivery and reducing toxicity. This novel biomimetic approach enhances nanoparticle delivery systems by leveraging cell-derived vesicles.
Area of Science:
- Biomaterials science
- Nanotechnology
- Cell biology
Background:
- Developing non-invasive nanoparticle delivery platforms with biomimetic properties is crucial for reducing toxicity and enhancing targeting.
- Existing methods face technical challenges, driving the search for improved biomimetic approaches like cell-derived vesicles.
- Giant plasma membrane vesicles (GPMVs) closely mimic intact cell membranes in composition, protein arrangement, and physical properties.
Conclusions:
- A novel technique enables nanoparticle loading within GPMVs via cell plasma membrane vesiculation.
- This approach facilitates the encapsulation of challenging nanoparticle types and improves cellular delivery.
- GPMVs offer a promising platform for developing highly effective, cell membrane-based nanoparticle and drug delivery systems with reduced toxicity.
