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Chronic kidney disease and gut microbiota.
Siamak Amini Khiabani1, Mohammad Asgharzadeh2, Hossein Samadi Kafil3
1Research center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran.
Heliyon
|August 23, 2023
Summary
The gut microbiome influences chronic kidney disease (CKD) progression through uremic toxins. Targeting the gut-kidney axis with interventions like probiotics may slow renal failure and reduce inflammation.
Area of Science:
- Microbiology
- Nephrology
- Systems Biology
Background:
- Gut dysbiosis is linked to hypertension, a CKD risk factor.
- Elevated uremic toxins from gut dysbiosis accelerate CKD progression.
- The gut-kidney axis plays a role in kidney stones and IgA nephropathy (IgAN).
Purpose of the Study:
- To explore the complex relationship between gut microbiota and chronic kidney disease (CKD).
- To investigate the potential of targeting the gut-kidney axis for CKD treatment.
- To understand the role of metabolites and host-gut microbiota interactions.
Main Methods:
- Metabolome-microbiome studies to analyze host-gut microbiota interactions.
- Systems biology approaches examining protein and transporter networks (SLC, ABC).
- Review of existing research on gut microbiota composition and CKD.
Main Results:
- Gut dysbiosis is associated with increased uremic toxins, worsening CKD.
- The gut-kidney axis is implicated in kidney stone formation and IgAN.
- Metabolome-microbiome studies show promising results in understanding host-gut interactions.
Conclusions:
- Further multi-omic research is needed to fully understand the gut microbiota-CKD correlation.
- Studying the gut-liver-kidney axis communication offers new therapeutic avenues for CKD.
- Probiotic interventions show potential for reducing uremic toxins and slowing CKD progression.
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