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Human Genetics

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...

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Updated: Jul 18, 2025

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

An Update on Precision Medicine Advances In Neurodevelopmental Disorders.

Dana M Lapato^1,2, Ashlee A Moore^2,3, Robert Findling³

¹Department of Human and Molecular Genetics, Virginia Commonwealth University.

Psychiatric Annals

|August 23, 2023

Summary

This summary is machine-generated.

Precision medicine advances personalized treatments for neurodevelopmental disorders like autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). Pharmacogenetics, focusing on genes like CYP2D6, guides tailored therapies for better outcomes.

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Area of Science:

Neurodevelopmental Disorders
Pharmacogenetics
Precision Medicine

Background:

Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) are common neurodevelopmental disorders impacting multiple life domains.
Current treatments for ASD and ADHD have limitations, highlighting the need for more personalized therapeutic strategies.
The Precision Medicine Initiative aims to shift from a one-size-fits-all approach to individualized medical care.

Purpose of the Study:

To review current research on personalized treatment approaches for ASD and ADHD.
To provide an update on the field of pharmacogenetics and "therapy-genetics" for these conditions.
To encourage clinical adoption of pharmacogenetic testing aligned with FDA guidelines.

Main Methods:

Literature review of pharmacogenetic research in ASD and ADHD.
Focus on key genes involved in drug metabolism, particularly the cytochrome P450 family (e.g., CYP2D6, CYP2C19).
Analysis of "therapy-genetics" advancements in neurodevelopmental disorder treatment.

Main Results:

Pharmacogenetic testing primarily targets cytochrome P450 enzymes, crucial for metabolizing many medications.
Specific gene variants (e.g., CYP2D6, CYP2C19) influence drug efficacy and safety in individuals with ASD and ADHD.
Emerging "therapy-genetics" approaches offer potential for highly individualized treatment plans.

Conclusions:

Personalized medicine, driven by pharmacogenetics, holds significant promise for improving ASD and ADHD treatments.
Clinicians should consider pharmacogenetic testing to optimize medication selection and dosage.
Adherence to FDA recommendations for pharmacogenetic testing is crucial for advancing patient care.