Randomized Trial Comparing Prediction Accuracy of Two Swept Source Optical Coherence Tomography Biometers

Area of Science:

• Ophthalmology
• Biomedical Engineering
• Medical Devices

Background:

• Accurate biometry is crucial for successful intraocular lens (IOL) power calculation in cataract surgery.
• Standard keratometry and Total Keratometry measurements can influence refractive outcomes.
• Comparing new biometry devices to established ones is essential for clinical adoption.

Purpose of the Study:

• To compare the refractive prediction accuracy of the Argos biometer (using standard keratometry) with the IOLMaster 700 (using Total Keratometry).

Main Methods:

• A randomized, prospective study involving 80 patients.
• Preoperative biometry was performed using both Argos and IOLMaster 700 devices.
• Prediction errors were calculated based on 1-month postoperative manifest refraction after cataract surgery and IOL implantation.

Main Results:

• Directional prediction errors were similar between devices (Argos: 0.07 ± 0.32 D; IOLMaster 700: 0.08 ± 0.34 D).
• Absolute prediction errors showed a statistically significant difference (Argos: 0.21 ± 0.25 D; IOLMaster 700: 0.25 ± 0.24 D), but this was not clinically significant.
• The percentage of eyes within 0.5 D of absolute prediction error was high for both: 91% for Argos and 88% for IOLMaster 700, with no significant difference.

Conclusions:

• The Argos and IOLMaster 700 biometers exhibit comparable refractive prediction accuracy in eyes with normal axial lengths.
• Despite a statistically significant difference in mean absolute prediction error, the variation between the devices is not clinically meaningful for cataract surgery outcomes.