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Nucleus-targeted drug delivery systems (NDDS) show promise for precision medicine. Overcoming biological barriers to deliver therapeutics into the nucleus is key for effective nucleus-targeted therapy.

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Area of Science:

  • Cell Biology
  • Pharmacology
  • Biotechnology

Background:

  • The nucleus is a critical organelle regulating cell functions like reproduction and metabolism.
  • Targeting the nucleus for drug delivery offers significant therapeutic potential in precision medicine.
  • Biological barriers impede the efficient transport of therapeutics into the nucleus.

Purpose of the Study:

  • To review recent advancements in nucleus-targeted drug delivery systems (NDDS).
  • To elucidate the mechanisms of drug transport across the nuclear envelope.
  • To discuss current challenges and future solutions for efficient NDDS.

Main Methods:

  • Description of nucleus and nuclear envelope structures.
  • Analysis of drug delivery strategies targeting the nucleus.
  • Review of recent literature on NDDS.

Main Results:

  • Understanding nuclear structures aids in designing effective drug delivery mechanisms.
  • Various strategies exist for crossing the nuclear envelope, with diverse applications.
  • Significant challenges remain in achieving efficient nucleus targeting and clinical translation.

Conclusions:

  • Nucleus-targeted drug delivery holds great promise for precision medicine.
  • Overcoming biological barriers is crucial for developing effective NDDS.
  • Further research is needed to enhance NDDS efficiency and facilitate clinical application.