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Graft versus Leukemia in 2023

Zane Chiad1, Aleksander Chojecki1

  • 11021 Morehead Medical Drive, Building 2, Charlotte, NC, 28204, USA.

Best Practice & Research. Clinical Haematology
|August 23, 2023
PubMed

Allogeneic hematopoietic stem cell transplantation (HSCT) is commonly utilized in the management of leukemia across multiple subtypes. Graft versus leukemia (GVL) is a critical component of successful transplantation and involves donor cells eradicating residual leukemia within the recipient. Graft versus host disease (GVHD) by contrast is a common complication of the transplantation process in which donor cells identify the recipient's various organ systems as foreign, thereby leading to a multitude of organ toxicities that can be described as autoimmune in nature. As both GVL and GVHD are mediated by a similar mechanism, these processes are felt to occur in tandem with one another. Here, we review the allogeneic HCT process in the context of GVL.

Keywords:
Allogeneic hematopoietic stem cell transplantationConditioning regimenGraft versus host diseaseGraft versus leukemiaHuman leukocyte antigenLeukemiaMinor histocompatibilityNatural killer cellsPost-transplant cyclophosphamideRegulatory T cells

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