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Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Related Experiment Video

Updated: Jul 18, 2025

Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models

Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models

Published on: June 16, 2022

Cancer Immunotherapy Using Bioengineered Micro/Nano Structured Hydrogels.

Esfandyar Askari¹, Mahdieh Shokrollahi Barough^1,2,3, Mehdi Rahmanian⁴

¹Laboratory for Innovations in Micro Engineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC V8P 5C2, Canada.

Advanced Healthcare Materials

|August 23, 2023

Summary

Micro/nanostructured hydrogels offer advanced cancer immunotherapy by enabling controlled release of therapeutic payloads. These materials show promise for local immune cell manipulation and activating systemic antitumor responses, inhibiting tumor recurrence.

Keywords:

caner immunotherapy implantable hydrogels injectable hydrogels nanogels nanovaccine sprayable hydrogels

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Last Updated: Jul 18, 2025

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Analysis of Cancer Cell Invasion and Anti-metastatic Drug Screening Using Hydrogel Micro-chamber Array HMCA-based Plates

Analysis of Cancer Cell Invasion and Anti-metastatic Drug Screening Using Hydrogel Micro-chamber Array HMCA-based Plates

Published on: October 25, 2018

Area of Science:

Biomaterials Science
Immunology
Drug Delivery

Background:

Hydrogels are 3D network materials widely used in therapeutic delivery, especially for cancer.
Micro and nanogels offer enhanced encapsulation and controlled release of various therapeutic agents compared to traditional hydrogels.
Cancer immunotherapy is a rapidly advancing field where micro/nanostructured hydrogels are gaining attention for their immune-enhancing properties.

Purpose of the Study:

To review the latest developments in cancer immunotherapy utilizing micro/nanostructured hydrogels.
To emphasize the function of these hydrogels based on their administration route.
To discuss the clinical translation potential of hydrogel-based cancer immunotherapies.

Main Methods:

Review of recent scientific literature on micro/nanostructured hydrogels in cancer immunotherapy.
Analysis of hydrogel properties related to payload release and immune cell interaction.
Evaluation of administration routes and their impact on therapeutic outcomes.

Main Results:

Micro/nanostructured hydrogels demonstrate significant potential in enhancing systemic anticancer immunity through engineered payload release.
Local administration of these hydrogels can effectively manipulate local immune cells for active and passive immunotherapies.
These carriers can activate systemic antitumor immune responses, inhibiting tumor metastasis and recurrence.

Conclusions:

Micro/nanostructured hydrogels are versatile platforms for cancer immunotherapy, offering controlled release and immune modulation.
Their application, particularly via local administration, holds promise for enhancing antitumor immunity and preventing recurrence.
Further clinical translation is warranted to realize the full potential of these advanced hydrogel-based therapies.