Behavioral and Neurological Effects of Edaravone and Noscapine in Albino Wistar Rats
Mamsa Rumaiza Hafizur Rehman, Angel Pavalu Godad1, Gaurav Mahesh Doshi1
1Department of Pharmacology, SVKM's Dr Bhanuben Nanavati College of Pharmacy, Mumbai, India.
Objective:
The purpose of the study was to explore Edaravone and Noscapine in anAlCl3-induced Alzheimer's disease (AD) model.
Methods:
Morris Water Maze (MWM), Novel Object Recognition (NOR), andY-maze tests with TNF-α, IL-1, IL-6, amyloid-β, CAT, SOD and MDAlevels were performed, followed by brain histology.
Results:
On the probe trial, the MWM demonstrated a decrease in escape latencyfollowed by an increase in the target quadrant. The NOR showeddiscrimination and recognition index scores and Y-maze, revealed arise in spontaneous alterations. TNF-α, IL-1, IL-6, amyloid-β, CATand MDA levels increased, while SOD levels dropped. The results werefound to be significant for combination full and half doses (***p <0.001, **p < 0.01). The treated group's histology ofbrain revealed mild neurodegeneration with hippocampal pyknoticnuclei.
Conclusions:
Thus, Edaravone and Noscapine can be used for thetreatment of AD. .
