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A pH/GSH/Glucose Responsive Nanozyme for Tumor Cascade Amplified Starvation and Chemodynamic Theranostics
Lihua Li1,2, Zefeng Lin3,4, Xingyi Xu3
1Future Institute of Technology, School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou 510515, P. R. China.
Abstract:
Nanozymes have brought enormous opportunities for disease theranostics. Here, a self-enhanced catalytic nanocrystal based on a bismuth-manganese core-shell nanoflower containing glucose oxide (GOx), termed BDS-GOx@MnO, was designed for 4T1 tumor theranostics in vitro and in vivo. The BDS-GOx@MnO nanozymes enable enhanced starvation treatment (ST) and chemotherapy (CDT) with high efficacy and exhibit sensitive tumor microenvironment (TME) responsive character for tumor therapy as well as for tumor-enhanced computer tomography (CT) and magnetic resonance (MR) diagnostic imaging. The characters and mechanism of the BDS-GOx@MnO nanozymes have also been systematically studied and revealed.
