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Updated: Jul 18, 2025

Development of Recombinant Proteins to Treat Chronic Pain
Published on: April 11, 2018
Managing intractable pain with neuraxial infusion at home
Shirley E Jones1, Katherine Bird2, Linda Maynard3
1Clinical Nurse Specialist, East Anglia's Children's Hospices.
Insights
This case study highlights successful home-based end-of-life care for a child with metastatic liver cancer using intrathecal drug delivery (ITDD). It emphasizes multidisciplinary support and risk management for pediatric palliative care (PPC).
Area of Science:
- Pediatric Palliative Care (PPC)
- Pain Management
- Oncology
Background:
- Complex pain management in pediatric oncology is challenging.
- Metastatic liver cancer presents significant symptom burden.
- Home-based end-of-life care (EoLC) is a priority for many families.
Purpose of the Study:
- To describe a case study of a 9-year-old child with metastatic liver cancer requiring intrathecal drug delivery (ITDD) for complex pain.
- To outline multi-modal symptom control strategies for home-based EoLC.
- To provide recommendations for nursing practice in pediatric palliative care.
Main Methods:
- Case study methodology.
- Implementation of multi-modal symptom control, including ITDD.
- Focus on achieving patient and parental wishes for home-based EoLC.
Main Results:
- Successful home-based EoLC was achieved using ITDD for complex pain.
- Challenges were safely addressed through robust risk assessment and mitigation.
- The case demonstrated the feasibility of extending PPC home care boundaries.
Conclusions:
- Rigorous risk assessment, clear communication, and specialized training are crucial for safe ITDD nursing practice in PPC.
- 24/7 access to specialist palliative care teams is essential for home-based care.
- This case supports the expansion of advanced home care services for children with complex needs.
Abstract:
A case study of a 9-year-old child with complex pain secondary to metastatic liver cancer, who eventually required intrathecal drug delivery (ITDD) of analgesia. Multi-modal symptom control strategies were deployed to achieve the child's and parental wishes for end-of-life care (EoLC) at home using ITDD. The following recommendations are made for nursing practice in paediatric palliative care (PPC); rigorous risk assessment, exemplary communication with the identification of a coordinating team, timely training needs assessment and the delivery of training from hospital based experts in ITDD practice, comprehensive symptom management plan and 24/7 access to specialist palliative care teams were essential for safe nursing practice. In this case, robust risk assessment and mitigations enabled challenges to be safely addressed with a successful outcome, extending the boundaries of PPC home care.
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