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Progress in Ocular Drug Delivery: Challenges and Constraints.
Ilva D Rupenthal1, Priyanka Agarwal2
1Buchanan Ocular Therapeutics Unit, Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand. i.rupenthal@auckland.ac.nz.
Handbook of Experimental Pharmacology
|August 24, 2023
Summary
Efficient ocular drug delivery to the posterior eye segment faces significant anatomical and physiological barriers. This review explores these challenges and highlights advanced delivery technologies for improved therapeutic outcomes.
Area of Science:
- Ophthalmology
- Pharmaceutics
- Biomedical Engineering
Background:
- The eye possesses dynamic and static barriers that restrict foreign substance entry, complicating therapeutic delivery.
- Efficient drug delivery to posterior segment tissues remains a significant challenge in ocular medicine.
Purpose of the Study:
- To describe anatomical and physiological challenges in ocular drug delivery.
- To discuss formulation parameter constraints for ocular therapeutics.
- To provide an overview of advanced ocular drug delivery technologies.
Main Methods:
- Literature review of ocular anatomy, physiology, and drug delivery barriers.
- Analysis of formulation constraints impacting drug penetration.
- Survey of current and late-stage advanced drug delivery systems for ocular applications.
Main Results:
- Ocular barriers present significant hurdles for systemic and topical drug delivery.
- Formulation design must overcome physiological limitations for effective ocular penetration.
- Advanced technologies show promise for enhanced ocular drug targeting and efficacy.
Conclusions:
- Overcoming ocular barriers is crucial for effective therapeutic delivery to the posterior segment.
- Innovative formulation strategies and advanced delivery systems are essential for future ocular treatments.
Keywords:
Dynamic barriersEyeEyedropsIntracameral implantsIntravitreal implantsMucus-penetrating particlesOcular drug deliveryPort delivery systemPunctum plugStatic barriersSuprachoroidal injectionMore Related Videos
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