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Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
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SGLT2 Inhibitors in Aging-Related Cardiovascular Disease: A Review of Potential Mechanisms

Yali Zhang1, Yufeng He1, Siqi Liu1

  • 1Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Key Laboratory of Medical Electrophysiology, Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China.

American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions
|August 24, 2023
PubMed

Insights

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) show promise in combating aging-related cardiovascular diseases. These drugs may prevent and treat conditions like atherosclerosis and heart failure in older adults by reducing inflammation and oxidative stress.

Area of Science:

  • Cardiology
  • Gerontology
  • Pharmacology

Background:

  • Population aging increases cardiovascular disease (CVD) risk, including atherosclerosis, heart failure, and hypertension in older adults.
  • Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are antidiabetic drugs with emerging cardiovascular benefits beyond glycemic control.

Purpose of the Study:

  • To review the role of SGLT2i in aging-related cardiovascular diseases.
  • To explore the potential of SGLT2i in preventing and treating CVD in the elderly population.

Main Methods:

  • Review of experimental models and recent studies on SGLT2i effects in cardiovascular disease.
  • Analysis of SGLT2i mechanisms including anti-inflammatory, antioxidant, and endothelial function improvement.

Main Results:

  • SGLT2i demonstrate beneficial effects in experimental cardiovascular disease models.
  • These drugs ameliorate aging-related CVD by inhibiting inflammation, reducing oxidative stress, and reversing endothelial dysfunction.

Conclusions:

  • SGLT2i possess therapeutic potential for aging-related cardiovascular diseases.
  • SGLT2i may serve as a novel preventative and therapeutic strategy for cardiovascular conditions in older adults.

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