Related Experiment Video
Updated: Jul 18, 2025
08:42
Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
Published on: October 22, 2014
27.4K
Relationship between sedentary behavior and endothelial dysfunction in a cross-sectional study in China
Ping-Ting Yang1, Sai-Qi Yang1, Yong-Mei He2
1Department of Health Management, The Third Xiangya Hospital, Central South University, Changsha, China.
Frontiers in Cardiovascular Medicine
|August 25, 2023
Summary
Increased leisure sedentary time is linked to a higher risk of vascular endothelial dysfunction. Reducing sedentary habits may improve vascular health in the general population.
Area of Science:
- Cardiovascular Health
- Vascular Biology
- Public Health
Background:
- Sedentary behavior is a known risk factor for various diseases.
- Previous research primarily focused on acute sedentary behavior's effects on vascular endothelial function.
- Limited data exists on the association between long-term sedentary lifestyle habits and vascular function in large populations.
Purpose of the Study:
- To investigate the correlation between self-reported sedentary behavior and peripheral vascular function.
- To assess vascular endothelial function in a large, real-world check-up population in China.
Main Methods:
- Recruited 13,220 participants from two health management centers in China (2017-2021).
- Collected data through questionnaires on lifestyle habits and brachial artery flow-mediated dilation (FMD) measurements.
- Utilized multivariable regression analysis to identify associations.
Main Results:
- Identified 3,205 participants (24.2%) with endothelial dysfunction (FMD ≤ 5.0%).
- A dose-response relationship was observed: longer leisure sedentary time correlated with increased risk of vascular endothelial dysfunction.
- Participants with >6 hours/day of leisure sedentary time showed a significantly higher risk (OR=1.618, P<0.001) compared to <2 hours/day.
Conclusions:
- Longer leisure sedentary time is associated with a higher prevalence of vascular endothelial dysfunction.
- Leisure sedentary behavior is identified as a significant risk factor for vascular endothelial dysfunction in the Chinese check-up population.
- Findings highlight the importance of reducing sedentary time for maintaining vascular health.
Related Concept Videos
01:30Coronary Artery Disease I: Introduction
20
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
20
01:30Atherosclerosis I: Introduction
10
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
10
01:26Coronary Artery Disease II: Pathophysiology
12
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
12