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Updated: Jul 18, 2025

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
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Thiolated Polymeric Hydrogels for Biomedical Applications: A Review.
Farhan Younas1, Muhammad Zaman1, Waqar Aman1
1Faculty of Pharmacy, University of Central Punjab, Lahore, Pakistan.
This review explores thiolated hydrogels, versatile polymer networks used in drug delivery and tissue engineering. It details their composition, modification methods, and diverse applications.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
Background:
- Hydrogels are 3D hydrophilic polymer networks stabilized by crosslinking.
- Thiolation modifies hydrogels for advanced applications, emerging in the early 21st century.
Approach:
- This review examines hydrogel ingredients, classification, and applications.
- It details thiolation methods, mechanisms, and various thiol-reducing agents.
Key Points:
- Thiolated hydrogels offer tunable properties for biomedical uses.
- Diverse polymers like dextran, gelatin, PEG, and chitosan are reviewed for thiolated hydrogel applications.
Conclusions:
- Thiolated hydrogels represent a significant advancement in biomaterials for regenerative medicine and drug delivery.
- Further research into thiolation chemistry and polymer selection will expand their therapeutic potential.
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