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Personalized Medicine in Cancer Pain Management.

Mohammad Raad1, William Omar Contreras López2,3, Alireza Sharafshah4

  • 1Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA.

Journal of Personalized Medicine
|August 25, 2023
PubMed
Summary

Personalized medicine and pharmacogenomics offer new ways to manage cancer pain. This review identifies key genes and biomarkers for tailored treatment strategies to improve patient quality of life.

Keywords:
cancercancer pain managementpainpersonalized medicinepharmacogenomicsvariant

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Area of Science:

  • Oncology
  • Pharmacogenomics
  • Pain Management

Background:

  • Cancer pain significantly impacts patient quality of life.
  • Effective cancer pain management (CPM) is crucial.
  • Personalized medicine approaches are emerging in CPM.

Purpose of the Study:

  • To systematically review CPM strategies, focusing on personalized medicine.
  • To introduce pharmacogenomics-based methods for cancer pain detection and treatment.

Main Methods:

  • Systematic literature review of PubMed (1990-2023) using keywords: cancer, pain, personalized medicine.
  • In silico analyses utilizing GeneCards, STRING-MODEL, miRTargetLink2, and PharmGKB databases.
  • Inclusion of 75 relevant publications after filtering 597 initial results.

Main Results:

  • Personalized medicine and pharmacogenomics are increasingly central to CPM.
  • Identified 57 evidence-based genes (e.g., CYP2D6, COMT, OPRM1) for personalized approaches.
  • Found 21 variants for potential whole-exome sequencing and suggested hsa-miR-34a-5p/hsa-miR-146a-5p as biomarkers.

Conclusions:

  • Personalized medicine, driven by pharmacogenomics, is the most promising strategy for effective CPM.
  • Pharmacogenomics enables tailored treatments to alleviate cancer pain.
  • Identified genes and biomarkers pave the way for advanced cancer pain management.